Helen Chun, Ph.D

Title: Assistant Professor of Biology

Department: Biology

Office: NSM A-138
Phone Extension: x3397
Email Username: hchun

Departmental Web Page News

Show All Publications Selected Presentations Grants Awarded

Publications

Lai, C-H, Chun, H.H., Nahas , S.A. , Mitui, M., Gamo, KM., Du, L., Gatti, R.A. (2004) Correction of ATM gene function by aminoglycoside-induced read-through of premature termination codons. Proc. Natl. Acad. Sci USA 101, 15676-15681.
Butch, A.W., Chun, H.H., Nahas , S.A. , Gatti, R.A. (2004) Immunoassay to Measure Ataxia-Telangiectasia Mutated Protein in Cellular Lysates. Clin. Chem. 50, 2302-2308.
Chun, H.H ., Cary, R.B., Lansigan, F., Rawlings, D.J., Gatti, R.A. (2004) ATM protein purified from vaccinia virus expression system: DNA binding requirements for kinase activation. Biochem Biophy Res Commun . 322, 74-81.
Mitui, M, Nahas, S.A., Chun, H.H., Gatti, R.A. (2004) Diagnosis of Ataxia-telangiectasia: ATM Mutations Associated with Cancer. Cancer Diagnostics: Current and Future Trends . Humana Press, p 473-488.
Chun, H.H ., Gatti, R.A. (2004) Review: Ataxia–telangiectasia, an evolving phenotype. DNA Repair, 3, 8-9, 1187-1196.
Chun, H.H ., Sun, X., Nahas, S.A. , Teraoka, S., Lai, C-H., Concannon, P., Gatti, R.A. (2003) Improved diagnostic testing for ataxia-telangiectasia by immunoblotting of nuclear lysates for ATM protein expression. Mol. Genet. Metab . 80, 437-443 .
Sun, X., Becker-Catania, S.G., Chun, H.H., Hwang, M.J., Huo, Y., Wang, Z., Mitui, M., Sanal, O., Chessa, L., Crandall, B., Gatti., R.A. (2002) Early diagnosis of ataxia-telangiectasia using radiosensitivity testing. J. Pediatr . 140, 724-731.
Chun, H.H ., Castellvi-Bel, S., Wang, Z., Nagourney, R.A., Plaeger, S., Becker-Catania, S.G., Naeim, F., Sparkes, R.S., Gatti., R.A. (2002) TCL-1, MTCP-1, and TML-1 gene expression profile in non-leukemic clonal proliferations associated with ataxia-telangiectasia. Int. J. Cancer 97, 726-731.
Gatti, R.A., Becker-Catania, S.G., Chun, H.H., Sun, X., Mitui, M., Lai, C-H, Khanlou, N., Babaei, M., Cheng, R., Clark, C., Huo, Y., Udar , N.C. , Iyer, R.K. (2001) The pathogenesis of ataxia-telangiectasia: Learning from a Rosetta Stone. Clinical Reviews in Allergy and Immunology . 20, 87-108.
Telatar, M., Teraoka, S., Wang, Z., Chun, H.H., Liang, T., Castellvi-Bel, S., et al., Udar, N., Borresen-Dale, A-L., Chessa, L., Bernatowska-Matuszkiewicz, E., Porras, O., Watanabe, M., Junker, A., Concannon, P., Gatti, R.A. (1998) Ataxia-telangiectasia: Identification and detection of founder-effect mutations in the ATM gene in ethnic populations. Am. J. Hum. Genet . 62, 86-97.
Latham, V.H., Herrera, S., Rostamiani, K., Chun, H.H., Oppenheimer, S.B. (1995) Rapid identification of lectin receptors and their possible function in sea urchin cell systems. Acta Histochem . 97, 373-382.
Latham, V.H., Ducut, J.L., Rostamiani, K., Chun, H.H., Lopez , M.E. , Herrera, S., Oppenheimer, S.B. (1995) A rapid lectin receptor binding assay: comparative evaluation of sea urchin embryo cell surface lectin receptors. Acta Histochem . 97, 89-97.
Daily, M.F., Latham, V.H., Garcia, C.M., Hockman, C.L., Chun, H., Oppenheimer, M.L., West, S.P., Rostaminay, K., Chao, R.L., Pollock, E.G., Oppenheimer, S.B. (1994) Producing exposed coat-free embryos. Zygote 2, 221-225.

Selected Presentations

Lai, C-H., Du, L., Chun, H.H., Nahas, S.A., Gamo, K.M., Gatti, R.A. (2005) Correction of ATM Gene Function by Readthrough of Premature Termination Codons. Poster presented at the 2005 International Workshop on Ataxia-Telangiectasia, ATM and the DNA Damage Response, Belgirate, Italy
Chun, H.H., Cary, R.B., Gatti, Rawlings, D.J., Gatti, R.A. (2003) Purification and Characterization of Vaccinia Expressed FLAG-ATM Protein. Poster presented at the annual meeting of the American Society of Human Genetics, Los Angeles, California
Nahas, S.A., Chun, H.H., Gatti, R.A. (2003) Immunoblotting of ATM Protein and Kinase Activity for Diagnosing A-T. Poster presented at the International Workshop on Ataxia-Telangiectasia 2003, Queensland, Australia
Butch, A., Chun, H.H., Sun, X., Gatti, R.A. (2002) Laboratory diagnosis of Ataxia-telangiectasia. Poster presented at the annual meeting of the Federation of Clinical Immunology Societies, San Francisco, California.
Butch, A., Chun, H.H., Sun, X., Gatti, R.A. (2002) Immunoassay for ATM (Ataxia-Telangiectasia, mutated) protein. Talk was presented at the annual meeting of the Association of Clinical Scientists, Salt Lake City, Utah
Chun, H.H., Gatti, R.A. (2002) Measurement of nuclear ATM protein and PI-3 kinase function. Poster was presented at the Ataxia-telangiectasia and ATM: 2002 International Symposium, Boston, Massachusetts.
Chun, H.H., Gatti, R.A. (2002) Structure/function studies of the ATM protein. Poster was presented at the Keystone Symposium, Structural Genomics: From Gene Sequence to Function, Breckenridge, Colorado.
Sun, X., Mitui, M., Chun, H., Crandall, B., Gatti., R. (2001) Clustering of ATM mutations in A-T patients with intermediate radiosensitivity. Poster was presented at the annual meeting of the American Society of Human Genetics, San Diego, California.
Telatar, M., Teraoka, S., Wright, J., Wang, Z., Sheikhavandi, S., Castellvi-Bel, S., Tai, L-Q., Chun, H., Liang, T., Concannon, P., Gatti, R.A. (1997) Characterization and detection of mutations in the ATM gene. Poster was presented at the annual meeting of the American Society of Human Genetics, Denver, Colorado.
Telatar, M., Wang, Z., Udar, N., Liang, T., Chun, H.H., Concannon, P., Gatti, R.A. (1996) Detection of common ATM mutations by user-friendly assays. Poster was presented at the annual meeting of the American Society of Human Genetics, San Francisco, California.

Grants Awarded

NIH Research Supplement to Promote Diversity in Health-Related Research Programs Graduate Student Support, #3R15GM080694-01S1. Period: August 2007 – July 2008
NIH Academic Research Enhancement Award (R15) Project: ATM Regulation via PP2A and Ceramide, # 1R15GM080694-01. Period: March 2007 – February 2010. See page 3.
CSUDH Sally Casanova Memorial RSCAAP Mini-grant Project: DNA Damage Repair Defects in Systemic Lupus Erythematosus Patients. Period: January – May 2005

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