Publications

• Carvalho,John, Michelle M. Arnold and Max L. Nibert. “Silencing and complementation of reovirus core and protein m 2: Functional correlations with m 2-microtubule association and differences between virus- and plasmid-derived m 2.” (2007) Virology. 364, 301-316.

• Carvalho, John, Jonghwa Kim and Max L. Nibert. “Reovirus m 2 protein is a nucleocytopalsmic shuttle protein that possesses classical nuclear import/export signal sequences and interacts with cellular karyopherins importin- a 1 and Crm1 in infected cells.” (in preparation for Journal of Biological Chemistry ).

• Carvalh, John, Paula G. Bertram, Hong Li, and X.F.S. Zheng. “Snf1-Glucose Signaling Pathway Regulates Interaction Between the TOR Regulated GATA-type Transcription Factor Gln3p and the Yeast Prion Precursor Protein Ure2p.” (in preparation for Molecular and Cellular Biology ).

• Carvalho, John. “Regulation of the GATA-Type Transcription Factor Gln3p by the Target of Rapamycin Protein (TOR).” (Published 2004; Dissertation completed 2003) UMI Dissertation Publications , Ann Arbor, Michigan : Proquest Information and Learning Company.

• Carvalho, John and X.F.S. Zheng. “Domains of Gln3p interacting with karyopherins, Ure2p and the target of rapamycin protein (TOR).” (2003) Journal of Biological Chemistry. 278, 16878-16886.

• Carvalho, John, Paula G. Bertram, Susan R. Wente, and X.F.S. Zheng. “Phosphorylation Regulates the Interaction Between Gln3p and the Nuclear Import Factor Srp1p.” (2001) Journal of Biological Chemistry . 276, 25359-25365.

• Choi, Jae, Paula G. Bertram, Ryan Drenan, John Carvalho, Heather H. Zhou and X.F.S. Zheng. “The FKBP12-Rapamycin-Associated Protein (FRAP) is a CLIP-170 Kinase.” (2002) EMBO Reports. 3, 988-994.

• Bertram, Paula, Jae Choi, John Carvalho, Ting-Fung Chan, Walden Ai, and X.F.S. Zheng. “Convergence of Snf1-Glucose and TOR-Nitrogen Signaling Pathways Onto Gln3p.” (2002) Molecular and Cellular Biology. 22, 1246-1252.

• Carvalho, John, Paula G. Bertram, and X.F.S. Zheng. “On the Mechanism of Regulated Nucleocytoplasmic Transport of Gln3.” (2001) Yeast. 18, S176.

• Chan, Ting-Fung, John Carvalho, Linda Riles, and X.F.S. Zheng. “A Chemical Genomics Approach Toward Understanding the Global Functions of the Target of Rapamycin Protein (TOR).” (2000) Proceedings of the National Academy of Sciences, U.S.A. 97, 13227-13232.

• Bertram, Paula, Jae Choi, John Carvalho, Walden Ai, Chenbo Zeng, and X.F.S. Zheng. “Tripartite Regulation of Gln3p By TOR, Ure2p and Phosphatases.” (2000) Journal of Biological Chemistry. 275, 35727-35733.

• Carvalho, John. “Genetic Analysis of the Ciguatera-Related Dinoflagellate Gambierdiscus toxicus.” (1994) The Fort Johnson Research Review . 6, 2-28.

Selected Presentations

• (2003) Presentation: John Carvalho. “Regulation of the GATA-type Transcription Gln3p by Ure2p, Nutrients, and the Target of Rapamycin Protein (TOR).” Harvard Medical School, Department of Molecular Genetics and Microbiology, Boston, MA.

• (2003) Presentation: John Carvalho. “Regulation of Gln3p Involving Ure2p, Nutrients, and TOR.” Massachusetts Institute of Technology, The Whitehead Institute, Cambridge, MA.

• (2002) Poster: John Carvalho, Paula G. Bertram, Jae H. Choi, Ting-Fung Chan, Wandong Ai, and X.F. Steven Zheng. “Mechanistic Studies of Glucose and Amino Acid Signaling in Yeast Saccharomyces Cerevisiae involving TOR, Snf1, and the Transcription Factor Gln3.” 2002 Yeast Genetics and Molecular Biology Conference, Madison, Wisconsin.

• (2002) Poster: Chan, Ting-Fung, John Carvalho, Linda Riles, and X.F.S. Zheng. “A Chemical Genomics Approach Toward Understanding the Global Functions of the Target of Rapamycin Protein (TOR).” 2002 Yeast Genetics and Molecular Biology Conference, Madison, Wisconsin.

• (2001) Poster: John Carvalho, Paula G. Bertram and X.F.S. Zheng. “Phosphorylation Regulates the Interaction Between Gln3p and its Nuclear Import Factor Srp1p.” 20th International Conference on Yeast Genetics and Molecular Biology in Prague, Czech Republic. Sponsored by the Czech Republic Academy of Sciences.

• (2000) Presentation: John Carvalho. “The TOR Signal Transduction Pathway.” University Wide Cell Signaling Seminar Series. Washington University School of Medicine, St. Louis, MO.

• (1999) Presentation Attendance/Co-sponsor: The Eugenics Movement in America: Dr. Garland Allen. The Ethical Society of St. Louis.

• (1999) Poster: John Carvalho, Paula Bertram, Jae Choi, and X.F.S. Zheng. “TOR as Sensor Linking Nitrogen Nutrients to Gene Expression.” Molecular Genetics Program Retreat. Washington University School of Medicine, Potosi, MO.

• (1998) Poster: Ting-Fung Chan, John Carvalho, Chenbo Zeng, Paula Bertram, and X.F.S. Zheng. “Target of Rapamycin.” Molecular Genetics Program Retreat. Washington University School of Medicine, Cedar Creek, MO.

• (1996) Conference: The International Yeast Genetics and Molecular Biology Conference, Madison, Wisconsin.

• (1996) Presentation: Biophilosophy: The Reductionist and Anti-Reductionist Debate. Philosophy Department. University of Dallas Braniff Graduate School. Irving, TX.

• 1995 Symposium: The National Science Foundation Bioethics Retreat. Baylor College of Medicine, Houston, TX.

• 1995 Presentation: Isolation of a Novel Orphan Receptor Gene Germ Cell Nuclear Factor (GCNF) From Mouse and Human cDNA Libraries. University of Texas Southwestern Medical Center at Dallas/University of Dallas Alumni Association. Dallas, TX.

• 1995 Presentation: Isolation of a Disease Gene in Male Infertility. Biology Department Research Presentation Series, University of Dallas. Irving, TX.

• 1994 Presentation: Population Genetics of Gambierdiscus toxicus. Grice Marine Biological Laboratory, James Island, South Carolina.

• 1994 Awards Lecture: Genetic Analysis of the Ciguatera-Related Dinoflagellate Gambierdiscus toxicus. Medical University of South Carolina, Charleston, SC.

• 1994 Presentation: Genetic Analysis of the Ciguatera-Related Dinoflagellate Gambierdiscus toxicus. National Marine Fisheries Service Marine Biotoxins Division, Fort Johnson, SC.

Grants Awarded

• 2007 College Natural and Behavioral Sciences Research Start-Up Grant, Project title: Study of Reovirus-Host Cell Interactions.

• 2004 NRSA Infectious Diseases and Basic Biological Mechanisms Training Grant (T32 Postdoctoral Fellowship), National Institutes of Health/Harvard Medical School

Awards, Honors

• XXV Annual ASV Postdoctoral Travel Award , American Society for Virology, 2006

• National Research Service Award (3-year Postdoctoral Fellowship F32) National Institutes of Health, 2004-present

• XXIII Annual ASV Postdoctoral Travel Award, American Society for Virology, 2004

• Marquis Who's Who in America, Marquis Biographical Journals, 2001-2003

• Marquis Who's Who in Science and Engineering, Marquis Biographical Journals, 2003

• Membership Award, New York Academy of Sciences, 1999

• The Cardinal Spellman Award For Potential in Graduate Program in Science, University of Dallas, 1996

• Summer Medical Scientist and Research Training Program Scholarship, Baylor College of Medicine, 1995

• Award for Research Excellence in Biomedicine, The Medical University of South Carolina, 1994

• Summer Biological Research Fellowship, College of Charleston, 1994

• The John B. O'Hara Chemical Sciences Award, The John B. O'Hara Chemical Sciences Program, 1992

• The Nevada Scholar's Award, Nevada State Legislature and Governor of the State of Nevada, 1992

• The Honor's Medallion Award, U.S. Department of Education, 1992